• Part Time
  • Iowa
Principal Scientist – Pharmaceutical Candidate Optimization
In this role, the candidate will provide direct scientific input and work closely with a team of experienced scientists focusing on characterization and stability testing of biotherapeutics in support of discovery efforts. The candidate is expected to have an in-depth understanding of qualitative and quantitative protein analyses using chromatography and high-resolution mass spectrometry with advanced data interpretation skills. He/she will work proactively with collaborators to assess the chemical stability of protein biologics during the course of developability and platform formulation fit assessments.  Additional responsibilities include the design and execution of in vitro or in vivo/ex-vivo analyses providing high impact analytical results to discovery programs. The candidate is expected to work closely with discovery project teams in our San Diego, CA site, as well as with collaborators at our Redwood City, CA, Seattle, WA, Princeton, NJ and Cambridge, MA sites.
Key Responsibilities
  • Be a hands-on presence in the laboratory
  • Help to specify, purchase, install and maintain analytical equipment for the PCO-DPAS laboratory in San Diego
  • Recruit and hire additional analytical professionals as portfolio demands dictate. Provide technical guidance, supervise, and develop scientific staff
  • Serve on and lead departmental, interdepartmental and project teams as needed
  • Write formal technical reports, methods and procedures when required
  • Adhere to all relevant compliance requirements
Qualifications and Experience
  • Ph.D. in analytical chemistry, biochemistry, pharmacology, or a related discipline with a minimum of 5 years of relevant industrial experience. 
  • Proven track record of scientific achievements in the analytical space. 
  • Extensive experience with high resolution mass spectrometry for characterization of therapeutics or endogenous protein targets is a must.
  • In-depth understanding of protein mass spectrometry, the position requires expertise in chromatography and sample preparation.
  • Broad-based understanding of drug discovery for a variety of drug modalities (small molecule, peptides, biologics, ADCs etc.). 
  • Strong interest in evaluating new technologies to enhance capabilities within the group is desired.  
  • Must possess extensive experience and understanding of mass spectrometric techniques particularly with developing and implementing LC-MS methods using TOF and Orbi-trap instruments for intact mass analysis, reduced and non-reduced peptide map analysis of antibodies, antibody variants and antibody-drug-conjugates.
  • Development and implementation of absolute quantitation LC-MS/MS methods from biological matrices such as serum, cell lysate, and tissue lysate.
  • Characterization of figures of merit for quantitative LC-MS/MS methods (LOD, LOQ, confidence intervals, etc.)
  • Strong capabilities in experimental design, execution and data interpretation.
  • Excellent oral and written communication skills and should be able to readily present and discuss bioanalytical approaches in support of drug discovery with collaborators. 
  • Ability to collaborate and build strong relationships with other disciplines in PCO (discovery toxicology and DMPK) for issue resolution and program advancement is essential.
  • Strong problem-solving and troubleshooting skills. 
  • A working knowledge of the repair and maintenance of standard analytical equipment is desired.
  • Ability to work independently.

To apply for this job please visit orbiterrecruiting.com.